Tuberculous meningitis: more evidence for protective effect of BCG

Does BCG vaccine prevent tuberculous meningitis?

The reported efficacy of BCG vaccine in preventing pulmonary tuberculosis varies from 0-80%; however, its efficacy in preventing tuberculous meningitis ranges from 52%-84%. A case-control study was conducted to assess the efficacy of BCG in preventing tuberculous meningitis in children. New cases of tuberculous meningitis, confirmed bacteriologically, were registered as cases. Controls were chi...

Impact of BCG on tuberculous meningitis in France in 1990.

Tuberculous meningitis in BCG vaccinated and unvaccinated children.

BACKGROUND A modified clinical presentation of tuberculous meningitis (TBM) in children vaccinated with BCG has been described in the literature. However, most reports are old and not based on actual comparisons and tests of significance. Also, neuroimaging features were not compared. With large scale BCG coverage, it becomes pertinent to describe the "modified" presentation and identify any si...

Tuberculous Meningitis

This is a brief review of the cases of tuberculous meningitis treated at Ham Green Hospital with streptomycin. Since 1948, seventy-seven cases have been admitted and of these thirty-five (45 per cent) are still living. For the purpose of this review seventeen cases are excluded?eight because they have been admitted too recently and nine, the earliest cases, either because they received quite in...

Corticosteroids for managing tuberculous meningitis

BACKGROUND Tuberculous meningitis, a serious form of tuberculosis that affects the meninges covering the brain and spinal cord, is associated with high mortality and disability among survivors. Corticosteroids have been used as an adjunct to antituberculous drugs to improve the outcome, but their role is controversial. OBJECTIVES To evaluate the effects of corticosteroids as an adjunct to ant...